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VOLUME 24 , ISSUE 5 ( May, 2020 ) > List of Articles


Severe Amlodipine Toxicity: A Case Rescued with Extracorporeal Membrane Oxygenation

Anand Sutar, Ashwini Murthy, Srinivas Budanur Chikkaswamy

Keywords : Amlodipine, Extracorporeal membrane oxygenation, Hypotension, Insulin

Citation Information : Sutar A, Murthy A, Chikkaswamy SB. Severe Amlodipine Toxicity: A Case Rescued with Extracorporeal Membrane Oxygenation. Indian J Crit Care Med 2020; 24 (5):365-366.

DOI: 10.5005/jp-journals-10071-23423

License: CC BY-NC 4.0

Published Online: 28-07-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Amlodipine is a widely prescribed drugs for the management of hypertension. Its toxicity is associated with severe myocardial depression and refractory hypotension. We present a case of a 28-year-old female known case of seizure disorder and depression who got admitted to our hospital with a history of consumption of 80 tablets of 5 mg amlodipine (total 400 mg). Patient presented to our hospital after 23 hours following consumption of the drug. Patient was managed in the intensive care unit (ICU) with mechanical ventilation support and intravenous infusion of noradrenalin, adrenalin, insulin-dextrose, and calcium gluconate. Due to refractory hypotension, venoarterial extracorporeal membrane oxygenation (VA-ECMO) was initiated on the same day. Patient was successfully managed and discharged home on the 8th day. This report highlights a rare case of a massive amlodipine overdose (400 mg) and ECMO as a rescue therapy.

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