Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 24 , ISSUE 6 ( June, 2020 ) > List of Articles


Withdraw Sedation Gently or Face Withdrawal Syndrome!

Citation Information : Withdraw Sedation Gently or Face Withdrawal Syndrome!. Indian J Crit Care Med 2020; 24 (6):381-382.

DOI: 10.5005/jp-journals-10071-23466

License: CC BY-NC 4.0

Published Online: 30-07-2020

Copyright Statement:  Copyright © 2020; The Author(s).


  1. Rogers MC. Do the right thing – pain relief in infants and children. N Engl J Med 1992;326(1):55–56. DOI: 10.1056/NEJM199201023260109.
  2. Anand KSJ, Hickey PR. Halothane-morphine compared with high dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery. N Engl J Med 1992;326(1):1–9. DOI: 10.1056/NEJM199201023260101.
  3. Fernández-Carrión F, Gaboli M, González-Celador R, Gómez de Quero-Masía P, Fernández-de Miguel S, Murga-Herrera V, et al. Withdrawal syndrome in the pediatric intensive care unit. Incidence and risk factors. Med Intensiva 2013;37(2):67–74. DOI: 10.1016/j.medin.2012.02.009.
  4. Best KM, Wypij D, Asaro LA, Curley MAQ. Patient, process and system predictors of iatrogenic withdrawal syndrome in children. Crit Care Med 2017;45(1):e7–e15. DOI: 10.1097/CCM.0000000000001953.
  5. Tobias JD. Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med 2000;28(6):2122–2132. DOI: 10.1097/00003246-200006000-00079.
  6. Arnold JH, Truog RD, Orav EJ, Scavone JM, Hershenson MB. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology 1990;73(6):1136–1140. DOI: 10.1097/00000542-199012000-00011.
  7. Arnold J, Truog R, Scavone J, FENTON T. Changes in the pharmacodynamic response to fentanyl in neonates during continuous infusion. J Pediatr 1991;119(4):639–643. DOI: 10.1016/s0022-3476(05)82419-9.
  8. Harris J, Ramelet A-S, van Dijk M, Pokorna P, Wielenga J, Tume L. Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals. Intensive Care Med 2016;42(6):972–986. DOI: 10.1007/s00134-016-4344-1.
  9. Tiacharoen D, Lertbunrian R, Veawpanich J, Suppalarkbunlue N, Anantasit N. Protocolized sedative weaning vs usual care in pediatric critically ill patients: a pilot randomized controlled trial. Indian J Crit Care Med 2020;24(6):451–458.
  10. Fonsmark L, Rasmussen YH, Carl P. Occurrence of withdrawal in critically ill sedated children. Crit Care Med 1999;27(1):196–199. DOI: 10.1097/00003246-199901000-00052.
  11. Katz R, Kelly HW, Hsi A. Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion. Crit Care Med 1994;22(5):763–767. DOI: 10.1097/00003246-199405000-00009.
  12. Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, Cheifetz IM, et al. Protocolised sedation versus usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomised clinical trial. JAMA 2015;313(4):379–389. DOI: 10.1001/jama.2014.18399.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.