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VOLUME 24 , ISSUE 12 ( December, 2020 ) > List of Articles

EDITORIAL

Adrenomedullin in Sepsis: Finally, a Friend or an Enemy?

Keywords : Adrenomedullin, Lipopolysaccharides, Sepsis

Citation Information : Adrenomedullin in Sepsis: Finally, a Friend or an Enemy?. Indian J Crit Care Med 2020; 24 (12):1151-1153.

DOI: 10.5005/jp-journals-10071-23669

License: CC BY-NC 4.0

Published Online: 26-12-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Adrenomedullin (ADM) is a 52 amino acid containing free circulating vasoactive peptide hormone found to be active in various pathophysiological states including sepsis. High ADM levels at admission have been correlated with vasopressor requirements, organ dysfunction, and mortality in sepsis patients. ADM stimulation results in vasodilation and loss of vascular resistance in humans resulting in hypotension with the potential for negative impact in septic shock. However, in vitro human and animal experiments have shown that ADM decreases hyperpermeability and capillary leak, thus having an endothelial barrier stabilizing effect during septic shock. Adrenomedullin thus appears to be a double-edged weapon. This editorial critically reviews the article by Daga et al. who evaluated serum ADM as a prognostic marker to review the gender-related difference in mortality pattern, and also the correlation of ADM level to APACHE II and SOFA scores. The role of adrenomedullin in sepsis and the potential developments in the future have been discussed concisely.


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