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VOLUME 25 , ISSUE 8 ( August, 2021 ) > List of Articles


Candida parapsilosis Prosthetic Valve Endocarditis: A Multifaceted Problem

Vikas Deswal

Citation Information : Deswal V. Candida parapsilosis Prosthetic Valve Endocarditis: A Multifaceted Problem. Indian J Crit Care Med 2021; 25 (8):839-840.

DOI: 10.5005/jp-journals-10071-23941

License: CC BY-NC 4.0

Published Online: 12-08-2021

Copyright Statement:  Copyright © 2021; The Author(s).


  1. Falcone M, Barzaghi N, Carosi G, Grossi P, Minoli L, Ravasio V, et al. Candida infective endocarditis: report of 15 cases from a prospective multicenter study. Medicine (Baltimore) 2009;88(3):160–168. DOI: 10.1097/MD.0b013e3181a693f8.
  2. Rivoisy C, Vena A, Schaeffer L, Charlier C, Fontanet A, Delahaye F, et al. Prosthetic valve Candida spp. endocarditis: new insights into long-term prognosis—the ESCAPE study. Clin Infect Dis 2018;66(6): 825–832. DOI: 10.1093/cid/cix913.
  3. Neji S, Hadrich I, Trabelsi H, Abbes S, Cheikhrouhou F, Sellami H, et al. Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens. J Biomed Sci 2017;24(1):67. DOI: 10.1186/s12929-017-0376-2.
  4. Mete B, Zerdali EY, Aygun G, Saltoglu N, Balkan II, Karaali R, et al. Change in species distribution and antifungal susceptibility of candidemias in an intensive care unit of a university hospital (10-year experience). Eur J Clin Microbiol Infect Dis 2021;40(2):325–333. DOI: 10.1007/s10096-020-03994-6.
  5. Clancy CJ, Nguyen MH. Finding the “missing 50%” of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. Clin Infect Dis 2013;56(9):1284–1292. DOI: 10.1093/cid/cit006.
  6. John MD, Hibberd PL, Karchmer AW, Sleeper LA, Calderwood SB. Staphylococcus aureus prosthetic valve endocarditis: optimal management and risk factors for death. Clin Infect Dis Off Publ Infect Dis Soc Am 1998;26(6):1302–1309. DOI: 10.1086/516378.
  7. Pizzi MN, Roque A, Fernández-Hidalgo N, Cuéllar-Calabria H, Ferreira-González I, Gonzàlez-Alujas MT, et al. Improving the diagnosis of infective endocarditis in prosthetic valves and intracardiac devices with 18F-fluordeoxyglucose positron emission tomography/computed tomography angiography. Circulation 2015;132(12): 1113–1126. DOI: 10.1161/CIRCULATIONAHA.115.015316.
  8. Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, et al. 2015 ESC Guidelines for the management of infective endocarditis. Eur Heart J 2015;36(44):3075–3128. DOI: 10.1093/eurheartj/ehv319. Available from:
  9. Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis 2016;62(4):e1–e50. DOI: 10.1093/cid/civ933.
  10. Baddour LM, Wilson WR, Bayer AS, Fowler VG, Tleyjeh IM, Rybak MJ, et al. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications. Circulation 2015;132(15):1435–1486. DOI: 10.1161/CIR.0000000000000296.
  11. Steinbach WJ, Perfect JR, Cabell CH, Fowler VG, Corey GR, Li JS, et al. A meta-analysis of medical versus surgical therapy for Candida endocarditis. J Infect 2005;51(3):230–247. DOI: 10.1016/j.jinf.2004.10.016.
  12. López-Ciudad V, Castro-Orjales MJ, León C, Sanz-Rodríguez C, de la Torre-Fernández MJ, de Juan-Romero MAP, et al. Successful treatment of Candida parapsilosis mural endocarditis with combined caspofungin and voriconazole. BMC Infect Dis 2006;6:73. DOI: 10.1186/1471-2334-6-73.
  13. Lye DCB, Hughes A, O'Brien D, Athan E. Candida glabrata prosthetic valve endocarditis treated successfully with fluconazole plus caspofungin without surgery: a case report and literature review. Eur J Clin Microbiol Infect Dis 2005;24(11):753–755. DOI: 10.1007/s10096-005-0038-2.
  14. Arnold CJ, Johnson M, Bayer AS, Bradley S, Giannitsioti E, Miró JM, et al. Candida infective endocarditis: an observational cohort study with a focus on therapy. Antimicrob Agents Chemother 2015;59(4):2365–2373. DOI: 10.1128/AAC.04867-14.
  15. Lefort A, Chartier L, Sendid B, Wolff M, Mainardi J-L, Podglajen I, et al. Diagnosis, management and outcome of Candida endocarditis. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis 2012;18(4):E99–E109. DOI: 10.1111/j.1469-0691.2012.03764.x.
  16. Ponnambath DK, Gopalakrishnan A, Pillai VV, Kaviyil JE, Raja K. Clinical Profile of Prosthetic Valve Endocarditis due to Candida parapsilosis: A 11-year Retrospective Observational Study from a Quaternary Cardiac Referral Institute in India. Indian J Crit Care Med 2021;25(8):857-862.
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