Indian Journal of Critical Care Medicine

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 25 , ISSUE 8 ( August, 2021 ) > List of Articles


Off-label Medication Use: A Double-edged Sword

Vandana Agarwal

Citation Information : Agarwal V. Off-label Medication Use: A Double-edged Sword. Indian J Crit Care Med 2021; 25 (8):845-846.

DOI: 10.5005/jp-journals-10071-23951

License: CC BY-NC 4.0

Published Online: 12-08-2021

Copyright Statement:  Copyright © 2021; The Author(s).


  1. Gota V, Divatia JV. Off-label use of drugs: an evil or a necessity? Indian J Anaesth 2015;59(12):767. DOI: 10.4103/0019-5049.171555.
  2. Gore R, Chugh PK, Tripathi CD, Lhamo Y, Gautam S. Pediatric off-label and unlicensed drug use and its implications. Curr Clin Pharmacol 2017;12(1):18–25. DOI: 10.2174/1574884712666170317161935.
  3. Pratico AD, Longo L, Mansueto S, Gozzo L, Barberi I, Tiralongo V, et al. Off-label use of drugs and adverse drug reactions in pediatric units: a prospective, multicenter study. Curr Drug Saf 2018;13(3):200–207. DOI: 10.2174/1574886313666180619120406.
  4. Smithburger PL, Buckley MS, Culver MA, Sokol S, Lat I, Handler SM, et al. A multicenter evaluation of off-label medication use and associated adverse drug reactions in adult medical ICUs. Crit Care Med 2015;43(8):1612–1621. DOI: 10.1097/CCM.0000000000001022.
  5. Lat I, Micek S, Janzen J, Cohen H, Olsen K, Haas C. Off-label medication use in adult critical care patients. J Crit Care 2011;26(1):89–94. DOI: 10.1016/j.jcrc.2010.06.012.
  6. highAlert2018new-Oct2018-v1.pdf [Internet]. [cited 2021 Jul 6]. Available from:
  7. Gérard A, Romani S, Fresse A, Viard D, Parassol N, Granvuillemin A, et al. “Off-label” use of hydroxychloroquine, azithromycin, lopinavir-ritonavir and chloroquine in COVID-19: a survey of cardiac adverse drug reactions by the French Network of Pharmacovigilance Centers. Therapie 2020;75(4):371–379. DOI: 10.1016/j.therap.2020.05.002.
  8. Sebastian S, Justin S, Athira PS, Daniel L, Sathyamurthy G, Menaka K, et al. Role of clinical pharmacist in medication management of inotropes and vasopressors in intensive care unit. Indian J Pharm Pract 2020;13(2):138–144. DOI: 10.5530/ijopp.13.2.21.
  9. Sivakumar MN, Veerasekar G. Impact of clinical pharmacist in an Indian Intensive Care Unit. Indian J Crit Care Med 2016;20(2):78–83. DOI: 10.4103/0972-5229.175931.
  10. Chapuis C, Albaladejo P, Billon L, Catoire C, Chanoine S, Allenet B, et al. Integrating a pharmacist into an anaesthesiology and critical care department: is this worthwhile? Int J Clin Pharm 2019;41(6):1491–1498. DOI: 10.1007/s11096-019-00909-0.
  11. Kannan S, Bahl A, Khosla PP. Knowledge and perception of off-label drug use amongst prescribing physicians in a tertiary care hospital. Int J Risk Saf Med 2015;27(4):219–223. DOI: 10.3233/JRS-150664.
  12. Liu L, Yang H-Y, Lou Y, Miao J, Lu X-Y, Zhao Q-W, et al. Off-label prescriptions in intensive care unit: the Chinese experience. Ther Clin Risk Manag 2018;14:195–202. DOI: 10.2147/TCRM.S146425.
  13. Prgomet M, Li L, Niazkhani Z, Georgiou A, Westbrook JI. Impact of commercial computerized provider order entry (CPOE) and clinical decision support systems (CDSSs) on medication errors, length of stay, and mortality in intensive care units: a systematic review and meta-analysis. J Am Med Inform Assoc 2017;24(2):413–422. DOI: 10.1093/jamia/ocw145.
  14. Raut A, Krishna K, Adake U, Sharma AA, Thomas A, Shah J. Off-label Drug Prescription Pattern and Related Adverse Drug Reactions in the Medical Intensive Care Unit. Indian J Crit Care Med 2021;25(8):878–883.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.