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VOLUME 25 , ISSUE 9 ( September, 2021 ) > List of Articles


Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation

Prahlad Prabhudesai, Indu Khosla, Satish Kulkarni, Manish Kumar Arya, Abha Pandey, Namrata Yadav

Keywords : Extracorporeal membrane oxygenation, Pulmonary alveolar proteinosis, Whole lung lavage

Citation Information : Prabhudesai P, Khosla I, Kulkarni S, Arya M K, Pandey A, Yadav N. Bilateral Whole Lung Lavage in Hereditary Pulmonary Alveolar Proteinosis in a 4-year-old Child Using Extracorporeal Membrane Oxygenation. Indian J Crit Care Med 2021; 25 (9):1069-1072.

DOI: 10.5005/jp-journals-10071-23968

License: CC BY-NC 4.0

Published Online: 08-09-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


The hereditary form of pulmonary alveolar proteinosis (PAP) is an uncommon entity. We report a case of PAP due to colony-stimulating factor 2 receptor alpha (CSF2RA) gene mutation. The standard of care includes whole lung lavage (WLL). We faced two challenges: Firstly, a severely hypoxemic patient, and secondly, the nonavailability of appropriate size of double-lumen endotracheal tube for pediatric patients for a WLL while permitting single-lung ventilation. Hence, we performed WLL using venovenous extracorporeal membrane oxygenation (VV ECMO) with a successful outcome. The patient has been discharged and is off oxygen support since more than a year. There are only a few case reports of children having hereditary PAP treated with WLL using ECMO in Indian and Western literature.

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