Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 25 , ISSUE 12 ( December, 2021 ) > List of Articles

Original Article

Clinical Course and Outcome of Critically Ill Obese Patients with COVID-19 Admitted in Intensive Care Unit of a Single Center: Our Experience and Review

Venkata Ganesh, Rakesh Kumar, Nishant Patel, Arshad Ayub, Kapil D Soni

Keywords : Coronavirus disease-2019, Obesity, Pandemic, Predictors of mortality

Citation Information : Ganesh V, Kumar R, Patel N, Ayub A, Soni KD. Clinical Course and Outcome of Critically Ill Obese Patients with COVID-19 Admitted in Intensive Care Unit of a Single Center: Our Experience and Review. Indian J Crit Care Med 2021; 25 (12):1382-1386.

DOI: 10.5005/jp-journals-10071-24047

License: CC BY-NC 4.0

Published Online: 17-12-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Abstract

Introduction: Obesity has been considered as one of the independent risk factors for a severe form of coronavirus disease-2019 (COVID-19) and relationship between obesity, critical illness, and infection is still poorly understood. We herein discuss clinical course and outcome of critically ill obese patients with COVID-19 admitted to critical care unit. Materials and methods: We retrospectively analyzed data of critically ill obese patients hospitalized with COVID-19 over a span of 6 months. Management was guided according to the institutional protocol. Collected data included demographic parameters (age, sex, comorbidities, and body mass index (BMI)), complications, inflammatory markers (interleukin (IL)-6, Ferritin), length of mechanical ventilation, length of intensive care unit (ICU) stay, and inhospital death. Results: There was no appreciable difference in terms of demographics, inflammatory markers, predictors of mortality scores, and comorbidity indices between the survivors and nonsurvivors. Among outcome analysis, there was a statistically significant difference between ventilator days between survivors and nonsurvivors (p = 0.003**). Conclusion: Obesity itself is a significant risk factor for severe COVID-19 infection; however, if efficiently managed and in a protocol-determined manner, it can have a favorable outcome.


HTML PDF Share
  1. More is not better: the complicated relationship between obesity, critical illness, and infection – PubMed. 2021. Available from: https://pubmed.ncbi.nlm.nih.gov/33638648/.
  2. Hendren NS, de Lemos JA, Ayers C, Das SR, Rao A, Carter S, et al. Association of body mass index and age with morbidity and mortality in patients hospitalized with COVID-19: results from the American Heart Association COVID-19 Cardiovascular Disease Registry. Circulation 2021;143(2):135–144. DOI: 10.1161/CIRCULATIONAHA.120.051936.
  3. Dhurandhar NV, Bailey D, Thomas D. Interaction of obesity and infections. Obes Rev 2015;16(12):1017–1029. DOI: 10.1111/obr.12320.
  4. Tsao Y-C, Chen J-Y, Yeh W-C, Li W-C. Gender- and age-specific associations between visceral obesity and renal function impairment. Obes Facts 2019;12(1):67–77. DOI: 10.1159/000496626.
  5. Gürün Kaya A, Öz M, Erol S, Çiftçi F, Çiledağ A, Kaya A. High flow nasal cannula in COVID-19: a literature review. Tuberk Toraks 2020;68(2):168–174. DOI: 10.5578/tt.69807.
  6. Muscogiuri G, Pugliese G, Barrea L, Savastano S, Colao A. Commentary: obesity: the “Achilles heel” for COVID-19? Metabolism 2020;108:154251. DOI: 10.1016/j.metabol.2020.154251.
  7. McNeill JN, Lau ES, Paniagua SM, Liu EE, Wang JK, Bassett IV, et al. The role of obesity in inflammatory markers in COVID-19 patients. Obes Res Clin Pract 2021;15(1):96–99. DOI: 10.1016/j.orcp.2020.12.004.
  8. King CS, Sahjwani D, Brown AW, Feroz S, Cameron P, Osborn E, et al. Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure. PLoS One 2020;15(11):e0242651. DOI: 10.1371/journal.pone.0242651.
  9. Smati S, Tramunt B, Wargny M, Caussy C, Gaborit B, Vatier C, et al. Relationship between obesity and severe COVID-19 outcomes in patients with type 2 diabetes: results from the CORONADO study. Diabetes Obes Metab 2021;23(2):391–403. DOI: 10.1111/dom. 14228.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.