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VOLUME 26 , ISSUE 4 ( April, 2022 ) > List of Articles

CASE REPORT

Case of Suspected SARS-CoV-2 Vaccine-induced Immune Thrombotic Thrombocytopenia: Dilemma for Organ Donation

Anand M Tiwari, Kapil G Zirpe, Sushma K Gurav, Lomesh B Bhirud, Rupali S Suryawanshi, Shilpa S Kulkarni

Keywords : Cerebral venous sinus thrombosis, COVID vaccine, Organ donation, PF4 antibody, Thrombocytopenia, Vaccine-induced prothrombotic immune thrombocytopenia (VIPIT), Vaccine-induced thrombotic thrombocytopenia (VITT)

Citation Information : Tiwari AM, Zirpe KG, Gurav SK, Bhirud LB, Suryawanshi RS, Kulkarni SS. Case of Suspected SARS-CoV-2 Vaccine-induced Immune Thrombotic Thrombocytopenia: Dilemma for Organ Donation. Indian J Crit Care Med 2022; 26 (4):516-519.

DOI: 10.5005/jp-journals-10071-24184

License: CC BY-NC 4.0

Published Online: 13-05-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Several vaccines were developed and rolled out at an unprecedented rate in response to the coronavirus disease-2019 (COVID-19) pandemic. Most vaccines approved globally by WHO for emergency use to combat the pandemic were deemed remarkably effective and safe. Despite the safety, rare incidences of vaccine-induced thrombosis and thrombocytopenia (VITT), sometimes known as vaccine-induced prothrombotic thrombocytopenia (VIPIT), have been reported. We report a case of young female with prothrombotic conditions and suspected VITT who developed catastrophic cerebral venous sinus thrombosis (CVST) and progressed to brain death. We highlight hurdles of organ retrieval from a brain-dead patient with suspected SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia. There is limited data and lack of substantial evidence regarding transplantation of organs from brain-dead patients with suspected VITT.


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