Indian Journal of Critical Care Medicine

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  28 (2024)
Volume  27 (2023)
Volume  26 (2022)
Volume  25 (2021)
Volume  24 (2020)
Volume  23 (2019)
Volume  22 (2018)
Volume  21 (2017)
Volume  20 (2016)
Volume  19 (2015)
Volume  18 (2014)
Volume  17 (2013)
Volume  16 (2012)
Volume  15 (2011)
Volume  14 (2010)
Volume  13 (2009)
Volume  12 (2008)
Volume  11 (2007)
Volume  10 (2006)
Volume  9 (2005)
Volume  8 (2004)
Related articles

VOLUME 26 , ISSUE S2 ( October, 2022 ) > List of Articles

EDITORIAL

Can we Reconcile Evidence-based Medicine with Personalized Medicine: Poised on a Cusp!

Atul Prabhakar Kulkarni, Rajesh Chandra Mishra

Keywords : Aggregated n-of-1 studies, Evidence-based medicine, N-of-1 studies, Personalized medicine, Randomized controlled trials

Citation Information :

DOI: 10.5005/jp-journals-10071-24354

License: CC BY-NC 4.0

Published Online: 31-10-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract
PDF Share
  1. Sallam HN. Aristotle, godfather of evidence-based medicine. Facts Views Vis Obgyn 2010;2(1):11–19. PMCID: PMC4154333.
  2. Guyatt GH. Evidence-based medicine. ACP J Club 1991;114:A-16. DOI: 10.7326/ACPJC-1991-114-2-A16.
  3. Claridge JA, Fabian TC. History and development of evidence-based medicine. World J Surg 2005;29:547–553. DOI: 10.1007/s00268-005-7910-1.
  4. Evidence-Based Medicine Working Group. Evidence-based medicine. A new approach to teaching the practice of medicine. JAMA 1992;268(17):2420–2425. DOI: 10.1001/jama.1992.03490170092032.
  5. Institute of Medicine (US) Committee to Advise the Public Health Service on Clinical Practice Guidelines. Clinical Practice Guidelines: Directions for a New Program. Field MJ, Lohr KN, editors. Washington (DC): National Academies Press (US); 1990.
  6. Woolf SH, Grol R, Hutchinson A, Eccles M, Grimshaw J. Clinical guidelines: Potential benefits, limitations, and harms of clinical guidelines. BMJ 1999;318(7182):527–530. DOI: 10.1136/bmj.318.7182.527.
  7. Sackett DL. Evidence-based medicine. Semin Perinatol 1997;21(1): 3–5. DOI: 10.1016/s0146-0005(97)80013-4.
  8. Diringer E, Yende S. Protocol-directed care in the ICU: Making a future generation of intensivists less knowledgeable? Crit Care 2012;16(2):307. DOI: 10.1186/cc11257.
  9. Vogenberg FR, Isaacson Barash C, Pursel M. Personalized medicine: Part 1: Evolution and development into theranostics. P T 2010;35(10):560–576. PMID: 21037908.
  10. Giamarellos-Bourboulis EJ, Opal SM. The role of genetics and antibodies in sepsis. Ann Transl Med 2016;4(17):328. DOI: 10.21037/atm.2016.08.63.
  11. Georgescu AM, Banescu C, Azamfirei R, Hutanu A, Moldovan V, Badea I, et al. Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression. BMC Infect Dis 2020;20(1):221. DOI: 10.1186/s12879-020-4910-6.
  12. Montoya-Ruiz C, Jaimes FA, Rugeles MT, López JÁ, Bedoya G, Velilla PA. Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis. Immunol Res 2016;64(5–6):1168–1178. DOI: 10.1007/s12026-016-8860-4.
  13. Hamburg MA, Collins FS. The path to personalized medicine. N Engl J Med 2010;363(4):301–304. DOI: 10.1056/NEJMp1006304.
  14. Schork NJ. Randomized clinical trials and personalized medicine: A commentary on deaton and cartwright. Soc Sci Med 2018;210: 71–73. DOI: 10.1016/j.socscimed.2018.04.033.
  15. Lillie EO, Patay B, Diamant J, Issell B, Topol EJ, Schork NJ. The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Per Med 2011;8(2):161–173. DOI: 10.2217/pme.11.7.
  16. Blackston JW, Chapple AG, McGree JM, McDonald S, Nikles J. Comparison of aggregated n-of-1 trials with parallel and crossover randomized controlled trials using simulation studies. Healthcare (Basel) 2019;7(4):137. DOI: 10.3390/healthcare7040137.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.