Appropriately Designed Studies are Needed before Thiamine and Vitamin C Plus Hydrocortisone are Judged Non-beneficial in Septic Shock
Josef Finsterer, Carla A Scorza, Fulvio A Scorza
Keywords :
Mortality, Sepsis, Shock, Thiamine, Vitamin C
Citation Information :
Finsterer J, Scorza CA, Scorza FA. Appropriately Designed Studies are Needed before Thiamine and Vitamin C Plus Hydrocortisone are Judged Non-beneficial in Septic Shock. Indian J Crit Care Med 2025; 29 (2):191-192.
Sharma S, Paneru HR, Shrestha GS, Shrestha PS, Acharya SP. Evaluation of the effects of a combination of vitamin C, thiamine and hydrocortisone vs hydrocortisone alone on ICU outcome in patients with septic shock: A randomized controlled trial. Indian J Crit Care Med 2024;28(11):1147–1152. DOI: 10.5005/jp-journals-10071-24852.
Alissa A, Alrashed MA, Alshaya AI, Al Sulaiman K, Alharbi S. Reevaluating vitamin C in sepsis and septic shock: A potential benefit in severe cases? Front Med (Lausanne) 2024;11:1476242. DOI: 10.3389/fmed.2024.1476242.
Fowler AA 3rd. Vitamin C: Rationale for its use in sepsis-induced acute respiratory distress syndrome (ARDS). Antioxidants (Basel) 2024;13(1):95. DOI: 10.3390/antiox13010095.
van der Poll T, Opal SM. Host-pathogen interactions in sepsis. Lancet Infect Dis 2008;8(1):32–43. DOI: 10.1016/S1473-3099(07)70265-7.